Though "Fire & Blood" offers no canonical explanation for what the disease actually is, the fact it appears to be a result of infections received from the swords of the throne itself hints towards something like sepsis or tetanus - and possibly a result of the most controversial tradition upheld by House of the Dragon's Targaryens: incest. While House of the Dragon's mysterious flesh-rotting disease isn't explained in "Fire & Blood," it is an adaptation of elements from the book which hints at King Viserys I Targaryen's impending doom. Urron had all his opponents and opposition slain at Nagga's Hill, earning the nickname of Redhand for spilling fellow Ironborn blood, and made the kingship of the Iron Islands hereditary. Urragon IV wanted to pass the throne to his great-nephew Urron Greyiron, against the wishes of the Kingsmoot. Erich avoided death by tossing his crown to the sea, showing his submission to the Drowned God. When his son Erich the Ugly tried to claim his father's throne, the Drowned Priest Galon Whitestaff threatened him with death and made him step down, since he had not been chosen by the Kingsmoot. House Greyiron once ruled as rock and salt kings of the Iron Islands until Urras Greyiron was chosen as the first King of the Iron Islands.
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